| abstract |
The subject of the invention is compounds corresponding to the formula (I): in which: - R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group; - R 2 represents a homopiperidin-1-yl, piperidin-1-yl, pyrrolidin-1-yl or azetidin-1-yl radical, or an amino (C 1 -C 6 )alkyl group; - or R 1 and R 2 , together with the nitrogen atom to which they are attached, constitute a piperazin-1-yl, 1,4-diazepan-1-yl, homopiperidin-1-yl, piperidin-1-yl, pyrrolidin-1-yl or azetidin-1-yl radical; - one of the two substituents R 3 , R 6 represents a Y-A-R 9 group; - Y represents an oxygen atom, or an -S(O) n -, -OSO 2 - or-N(R 18 )- group; ‑ A represents an unsubstituted (C 1 -C 4 )alkylene group; - R 9 represents an -OR 12 , -CN, ‑CO 2 H, NR 12 R 13 , -CONR 12 R 13 , -NR 15 COR 12 ,-CONHNH 2 , -CONHOH, -CONHSO 2 R 14 , ‑S(O) n R 14 , -SO 2 NR 12 R 13 , -NR 18 SO 2 R 14 , or-NR 15 SO 2 NR 12 R 13 group, or an aromatic heterocycle. The present invention also relates to the methods of preparation and the therapeutic applications of the compounds of formula (I). |