| abstract |
Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ 1(Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ 1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ 1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ 1 protein. |