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publicationDate 2012-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2275094-A3
titleOfInvention Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
abstract Disclosed are methods of intravenous administration of nanoparticulate drug formulations to a mammal to avoid adverse hemodynamic effects: by reducing the rate and concentration of the nanoparticles in the formulations; or by pretreating the subject with histamine; or by pretreating the subject with a desensitizing amount of the nanoparticulate drug formulations.
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