| abstract |
The invention provides fϊbronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecifϊc Fn3 -based binding molecules that bind to two or more targets simultaneously. The Fn3 -based binding molecules of the invention can also be linked together to form multispecifϊc Fn3-based binding molecules, and/or can be conjugated to a non-Fn3 moiety, such as, Human Serum Albumin (HSA), for improved half life and stability. The invention also provides methods for generating, screening and using Fn3 -based binding molecules in a variety of therapeutic and diagnostic applications. |