Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b53290ef881bc16e92cfbaf0cd9605a7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-604 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L29-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L29-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16 |
filingDate |
2004-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d6d58a27f731e22f7d28f18ae71baba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b760611119ca5b0988f8623daf3a506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d64fd04a5cdcc9c66410d32896af5faf |
publicationDate |
2011-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2272544-A1 |
titleOfInvention |
Implantable medical device with beneficial agent concentration gradient |
abstract |
An implantable medical device comprises: an implantable device body having a mural surface (26) and a luminal surface (24) and a plurality of holes (20) traversing both the mural and luminal surface; a therapeutic agent, a matrix (40), and a barrier layer (30) contained in each of the plurality of holes; wherein the holes each have a luminal opening and a mural opening and the barrier layer is positioned across the luminal opening, and the therapeutic agent is primarily delivered through the mural opening of the hole; wherein the therapeutic agent is present in both the barrier layer and the matrix, at different local concentrations, and the matrix is created in a stepwise manner, such that a concentration gradient of the therapeutic agents exists in the matrix. |
priorityDate |
2003-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |