http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2261659-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0aac8d1633f261cf5e41541073fe0fac |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-807 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-7703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54373 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-77 |
| filingDate | 2001-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_825a5b38fe0ecf8d60661d1f6960a33e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a0cdc73f3f8d7071b8aa7ed4942e0b5 |
| publicationDate | 2010-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2261659-A2 |
| titleOfInvention | Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variant) |
| abstract | The invention provides a method and apparatus for detection of binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are mainly of biological origin and/or determine parameters of living activity of biological objects, to substances that bind the said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components. n Binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by the light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light. The signal is represented by a spectrum; the sensor layer is more than 10 micrometers thick and exceeds the maximum-recorded wavelength by at least an order of magnitude; information about the binding being detected is obtained from analysis of a spectral shift of interference maximums and minimums. A plate, solid or porous, or a gap with two surfaces of a solid optical material is used as the sensor layer. As the surfaces are located at a distance of more than 10 micrometers, this allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of the superluminescent diodes or tunable semiconductor lasers as light sources, because it allows recording within their narrow spectrums a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher signal-to-noise ratio and sensitivity of the apparatus as compared with apparatus based on thin-film sensor layers. |
| priorityDate | 2000-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.