| abstract |
The present invention provides a method for synthesizing a compound of formulan nor a pharmaceutically acceptable salt thereof, wherein neach of A, A I , and A" is H; nX is COR I ; nR' is C 1-5 alkyl; nX I is N; nmis1; nn is 1; neach of E', E", E III , E IV , and E V is H; nE VI is C 1-5 alkyl; and neach of Z I and Z II individually is H or C 1-5 alkyl; n nor comprising coupling of a halo-substituted pyridine with an olefin containing protected amine functionality. |