| abstract |
The present invention relates to a method for selective preparing 4,17 (20)- E -pregnadiene-3,16-dione ( E -guggulsterone) of the formula (III) and 4,17 (20)- Z -pregnadiene-3,16-dione ( Z -guggulsterone) of the formula (IV) having an effect of lowering the elevated low density lipoprotein (LDL) and high levels of the cholesterol effectively, and elevating the low levels of the high density lipoprotein (HDL) from a easy-available steroid of the following formula (I). n Also, the present invention provides a method for preparation of the compound of the above formula (II). |