| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9bceffddb90b9b3da8a772212961764b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e28f227b7f05d951278a16b19bd0a129 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3519 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fad831861b420f08365f06fd6e9aacb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23574f6ef039bd3d070f2a68afc3202a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_208a821e6959d8e400a9ae20d6561632
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4c86588413828e34415650a163b046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dc8fa17cade0913043d20d02cdd0572 |
| publicationDate |
2010-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2226384-A1 |
| titleOfInvention |
Complex of polysaccharide and double-stranded rna |
| abstract |
An object of the present invention is to provide novel double-stranded RNA having an RNA interference effect, in which the cellular uptake and the resistance to enzymatic degradation are improved, without reducing the RNA interference effect. n The cellular uptake and the resistance to enzymatic degradation of a complex of a polysaccharide having a β-1,3-glucan skeleton and double-stranded RNA can be significantly improved while maintaining the RNA interference effect, by fulfilling the following conditions (i) to (iii): (i) the double-stranded RNA has a sense strand consisting of a base sequence complementary to a target sequence in a target gene and an antisense strand containing a base sequence complementary to the sense strand, and the double-stranded RNA can inhibit expression of the target gene; (ii) the double-stranded RNA has a single-stranded polydeoxyadenine bound directly or via a linker to the end of at least one of the sense strand and the antisense strand; and (iii) the polysaccharide and the single-stranded polydeoxyadenine form a complex. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3546577-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9801929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2742944-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2682462-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11203755-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013142832-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713636-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2865759-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2742944-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2682462-A1 |
| priorityDate |
2007-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |