http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2221621-A1

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filingDate 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99ba3136c9c0ad319d3f31a0890122c2
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publicationDate 2010-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2221621-A1
titleOfInvention Test strip and method for determining HDL cholesterol concentration from whole blood or plasma
abstract A multilayer test strip [20] and method of using the test strip [20] for determining concentration of HDL cholesterol in a whole blood sample. The inventive test strip [20] includes a two-stage blood separation mechanism, including a first glass fiber matrix [38] which separates most of the blood cells and an adjacent, second matrix [40] preferably also containing glass fibers that separates the remainder of the blood cells. The second layer [40] also precipates and retains non-HDL cholesterol, thereby providing plasma that is substantially free of red blood cells and substantially free of non-HDL cholesterol to a reaction layer [42]. Precipitation and retention on non-HDLs takes place by vertical or dead-end filtration in a single layer [40]. The reaction layer [42] produces a color, the intensity of which is proportional to the concentration of HDL cholesterol in the blood sample which is applied to the test strip. Advantageonsly, the inventive test strip [20] is a vertical flow device, which can be made more compact and operates more efficiently than a lateral flow device.
priorityDate 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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