| abstract |
Disclosed are inhibitors of PMRT type I methyltransferase and their use in pharmaceutical compositions containing a compound of general formula I wherein the radicals R 1 and R 2 are the same or different and are selected from the meanings hydrogen, straight or branched chain C 1-5 alkyl, or n is an integer between 3 and 5,n n n X is a heteroatom selected from O, S, NR 1 or has the meaning -CH 2 - and the radical Het is a 5-, 6- or 7-membered aromatic or non-aromatic ring containing 1 to 5 heteroatoms selected from N, S and O, which ring may optionally be substituted and may be a substituted or unsubstituted polycyclic ring, and pharmaceutically acceptable salts thereof. The compositions are for use as antitumor drugs. |