| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e96ca33f6f787323d29cd7e8453d3e31 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 |
| filingDate |
2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4843b2d5d6c75cbea9a0c7fd125e4eb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee2813f50c616d0a6097a8ada1794c18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a8d1291eb13d98509bb192afe63b06d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bb156912e5588a00cd68a426247a4bb |
| publicationDate |
2010-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2220229-A2 |
| titleOfInvention |
Mutant g-protein coupled receptors and methods for selecting them |
| abstract |
A method of producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to its parent GPCR, the method comprising: a) providing one or more mutants of a first parent GPCR with increased stability relative to the first parent GPCR b) identifying in a structural membrane protein model the structural motif or motifs in which the one or more mutants have at least one different amino acid residue compared to the first parent GPCR, and c) making one or more mutations in the amino acid sequence that defines a corresponding structural motif or motifs in a second parent GPCR, to provide one or more mutants of a second parent GPCR with increased stability relative to the second parent GPCR. Mutants of β-adrenergic receptor, adenosine receptor and neurotensin receptor are also disclosed. |
| priorityDate |
2007-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |