Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae6da34296d54b648baa249c974b6a1a |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 |
filingDate |
2008-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff758a496e303ccdbcae83b267dd51e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e9c24fe3a9bf1bea3de1cbcb661495a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e04b8538f704c9ec13095df5dd33dee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68fbccfe9b02844fbadaffa75f65eb5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccd92816a1d99ec015db4ff440c4a958 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56eab0fadfd8ae35cb86941dd92c519d |
publicationDate |
2010-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2219660-A1 |
titleOfInvention |
Modified il-4 mutein receptor antagonists |
abstract |
This invention relates to modified IL-4 mutein receptor antagonists comprising an IL- 4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL- 13 -mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life. |
priorityDate |
2007-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |