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publicationDate 2010-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2217704-A1
titleOfInvention Method for the promotion of angiogenesis, vascularization, or vascular repair or for the inhibition of tumor angiogenesis
abstract The invention relates to a method for influencing miR-92 expression in a cell, comprising the following steps: (a) a cell is provided; and (b1) miR-92 expression in the cell is reduced in order to promote vascularization or vascular repair by introducing an antisense molecule against miR-92 into the cell, or (b2) miR-92 expression in the cell is increased in order to inhibit tumor angiogenesis by introducing a construct into the cell, said construct containing an expressible miR-92 sequence. The invention further relates to a pharmaceutical composition containing an agent for reducing miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing miR-92 expression in a cell in the form of a construct for expressing miR-92.
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