| abstract |
The invention provides a reagent for detecting amyloid in a biological tissue which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid and is suppressed in toxicity such as mutagenicity. n The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof:n nwherein A 1 , A 2 , A 3 and A 4 independently represent a carbon or a nitrogen, and nR 3 is a group represented by the following formula:n nwherein R 1 is a radioactive halogen substituent; m is an integer of 0 to 4; and n is an integer of 0 or 1, provided that at least one of A 1 , A 3 , A 3 and A 4 represents a carbon, and R 5 binds to a carbon represented by A 1 , A 2 , A 3 or A 4 . |