| abstract |
A bio-adhesive supramacromolecular complex of the general formula (1): wherein R1 is an alkane unsubstituted or substituted with alkoxy groups; R2 is a lower alkane; R3 and R4 are long chain, optionally substituted, alkanes; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide; Z is a linking group; T1, T2, T3 and T4 are terminal groups; and m1, m2, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1 x 103 to 1 x 107 and Q has a molecular weight of about 1 x 103 to 1 x 107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described. |