http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2198878-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e29906c323d645bc29cffa611f65aa56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7de02e4b28736bfb52de8bb358be203e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate | 2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e8639b529523ec876734d147a6b7a27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a27de09e2275450c31cdfe1e03ff212f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f753d13757f5abb1bca816684a86d305 |
| publicationDate | 2010-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2198878-A1 |
| titleOfInvention | Polypeptide bombesin antagonists |
| abstract | There is provided a method of treating human hepatomas utilizing bombesin antagonist pseudopeptides of Formula I: n X-A 1 -A 2 -Trp-Ala-Val-Gly-His-Leu-¨-A 9 -Q(SEQ ID NO: 32) nwherein X is hydrogen, Hca, Hna, Hpp, Mpp or Naa, nA 1 is a D-, L- or DL-amino acid residue selected from the group consisting of Phe, p-HI-Phe, pGlu, Nal, Pal, Tpi, unsubstituted Trp or Trp substituted in the benzene ring by one or more members selected from the group consisting of F, Cl, Br, NH 2 or C 1-3 alkyl; or a peptide bond linking the acyl moiety of X (where present) to the alpha amino moiety of A 2 , nA 2 is Gin, Glu [-], Glu (Y), or His, wherein n[-] is a single bond, linking the gamma carboxyl moiety or the 3-propionyl moiety of A 2 with the alpha amino moiety of A 1 , nY is na) -OR 5 wherein R 5 is hydrogen, C 3 alkyl or phenyl; or nb) R 6 nwherein R 6 is hydrogen or C 1-3 alkyl; R 7 is hydrogen, C 1-3 alkyl or-NHCONH 2 . Leu-¨- is a reduced form of Leu wherein the C = O moiety of Leu is instead -CH 2 - such that the bond of this -CH 2 - moiety with the alpha amino moiety of the adjacent A 9 residue is a pseudopeptide bond. Suitably A 9 is Tac, MTac, or DMTac, nQ is NH 2 or -OQ' where Q' is hydrogen, C 1-10 alkyl, phenyl or phenyl-C 1-10 -alkyl; and the pharmaceutically acceptable acids or salts thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113105399-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3880691-A4 |
| priorityDate | 2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 155.