| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_189beddaebd257334afadc93dd8fedd0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea4b7081a25037292b5d60e7116d71b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_683994111261bb96c85d4c4fe740da95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e03675c33d04aa98b9af48d39ad3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe90663cf967b55ede527631a56b46ce |
| publicationDate |
2010-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2198037-A1 |
| titleOfInvention |
Chemo-enzymatic peptide synthesis via c-terminal ester interconversion |
| abstract |
The invention relates to a method for preparing an optionally N-protected amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester, comprising transesterifying the C-terminal t-alkyl ester of the amino acid or the C-terminal t-alkyl ester of the peptide with an alcohol (other than the t-alcohol corresponding to the t-alkyl group of the ester) in the presence of a hydrolytic enzyme (E. C. 3). The invention further relates to a method for preparing a peptide comprising coupling an activated, N-protected, amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester with an optionally C-terminal protected amino acid or an optionally C-terminal protected peptide via a peptide bond, in the presence of an enzyme catalysing peptidic bond formation. |
| priorityDate |
2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |