http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2182354-A1

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filingDate 2008-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d074c6aaf2e95ec070afcc562ad1eb6
publicationDate 2010-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2182354-A1
titleOfInvention Method for detection or measurement of abnormal prion protein involved in transmissible spongiform encephalopathy
abstract A pretreatment method of a specimen used for detecting or determining abnormal prion protein (PrPres) associated with transmissible spongiform encephalopathy (TSE), wherein n(1) a specimen which had been treated with proteinase K is heated in the presence of sodium dodecyl sulfate (SDS) to dissolve proteins and inactivate infectious activity in the specimen at the same time; (2) the specimen processed in the above (1) is cooled under a neutral condition to make abnormal prion protein (PrPres) associated with transmissible spongiform encephalopathy (TSE) aggregated; (3) the aggregate formed in the above (2) is separated from a solution; and (4) the separated PrPres aggregate is detected by the ultrasensitive chemiluminescence method.
priorityDate 2007-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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