| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_577a9d13ba46664f4caee5c48d5b022e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdf7b8916345b671dbfd9676e6b00021 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-04 |
| filingDate |
2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f3cec3365bbc224992633eb3db9530f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f043f15b46f7f14126b73fa1c70eec71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b13e657c60cab199e04a74c584c85ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b30b4e394bca37e5f96b747def300dbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_871f2722cac9277e75a1be19526d001f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf40a98392cd147107aa2137b9feeda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abbf1292b5c9ebab56328f178d79d4fb |
| publicationDate |
2011-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2173892-B1 |
| titleOfInvention |
Process for the preparation of penicillin or cephalosporin antibiotics |
| abstract |
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIPl and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic β-lactam antibiotics in the reaction mixture consisting of activated acyl- donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E.coli BL21 CCM 7394 as the biocatalyst. |
| priorityDate |
2007-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |