| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97c71b09235336e87e31f355e84098a1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-69 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 |
| filingDate |
2008-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627bdd2516ce05e9f3402bbf96e8ef11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dddf5cb2e8634929948993106945bf7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbe52a965224a6c8dd36e6b9528b947e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9a215dfd1041e6c6fc1bb571d9ff2fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8ed7b6a98f268cd333e0d7c81321ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af66e3e0066489ca1b1793828701516e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13b0bc785da5c30266fab8a64dffe29c |
| publicationDate |
2010-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2170841-A1 |
| titleOfInvention |
Process for introduction of hydroxyethoxy side chain in bosentan |
| abstract |
The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dirner impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders. |
| priorityDate |
2007-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |