| abstract |
A pharmaceutical composition for enhancing the expression of apoAI, which comprises a compound of formula (I):n nin which. nX 1 and X 2 are independently an aryl that may be optionally substituted, a heteroaryl that may be optionally substituted, a cycloalkyl that may be optionally substituted, an aryloxy that may be optionally substituted, a heteroaryloxy that may be optionally substituted, an arylthio that may be optionally substituted, a heteroarylthio that may be optionally substituted, a hydrogen, a halogen, a hydroxy, a lower alkyl that may be optionally substituted, a lower alkenyl that may be optionally substituted, a lower alkoxy that may be optionally substituted, a lower alkenyloxy that may be optionally substituted, a carboxy, a lower alkoxycarbonyl that may be optionally substituted, an acyl that may be optionally substituted, an amino that may be optionally substituted, or a carbamoyl that may be optionally substituted, provided that at least one of X 1 and X 2 is an aryl that may be optionally substituted, or a heteroaryl that may be optionally substituted; nring A is a pyridine ring, a pyrimidine ring, a pyrazine ring, a pyridazine ring, a triazine ring, a quinoline ring, a quinoxaline ring, or a phthalazine ring; nR 1 , R 2 , R 3 , R 4 and R 5 are independently a hydrogen, a halogen, a hydroxy, a lower alkyl that may be optionally substituted, a lower alkenyl that may be optionally substituted, a lower alkoxy that may be optionally substituted, a lower alkenyloxy that may be optionally substituted, a carboxy, a lower alkoxycarbonyl that may be optionally substituted, an acyl that may be optionally substituted, an amino that may be optionally substituted, or a carbamoyl that may be optionally substituted; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them. |