| abstract |
The present invention is directed to compounds, compositions and methods useful for treating inflammatory and immune-related diseases and conditions. The compounds are modulators of prostaglandin D2 (PGD2) receptors including CRTH2 and DP receptors. The subject compounds are carboxylic acid derivatives of formulae (II) and (III): Formula (II), (III), wherein, X represents a divalent linkage selected from -O-, -S(O)k-., -CRaRb-, -C(O)-, -NR8- and -C(NR9)- Y represents a divalent linkage selected from a single bond, -S(O)kNR10-, -C(O)NR10-, (C1-C4)alkylene, hetero(C2-C4)alkyIene, -N(R11)C(O)NR10- -N(R11)S(O)kNR10-, -N(R11)CO2-, -NR11-, -O- and -S(O)k-. Z represents -CO2R12, -C(O)NR12R13 or heteroaryl. L represents a divalent linkage selected from a single bond, (C1-C6)alkylene, (C2-C6)alkenylene, (C2-C6)alkynylene and (C2-C4)heteroalkylene. |