| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07addebfc9446dc5a9a77692ebf4dac1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 |
| filingDate |
2007-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6451ec36eb25761d5e51c69dd108d651
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c7018364ffa5dea05402927bcf94421
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebca871b3cff044e29b6b91e8ffc3683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f364d2cbe01728f96c441ca7aeffcddd |
| publicationDate |
2010-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2161253-A3 |
| titleOfInvention |
Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans |
| abstract |
The present invention is directed to processes for the synthesis of morphinans. In particular, a process tor coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl 3 that is necessary to form the 3,4-dihydroisoquinoline. |
| priorityDate |
2006-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |