| abstract |
This invention relates to spirocyclic derivatives, compositions containing and the uses of, such derivatives. The spirocyclic derivatives of the present invention are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. The invention provides a compound of formula (I): wherein: X is O. S or N-CN; R 1 is halogen or CN; A is a single bond, CH 2 , 0 or S; B is a single bond, CH 2 or OCH 2 ; each R 2 is independently halogen, (C 1-6 )alkyl (optionally substituted by 1 to 3 fluorine atoms), OH, (C 1-6 )alkoxy, (C 1-6 )alkylthio or CN; R 3 is selected from the following groups (i) to (x). |