http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2153362-A2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2592fdd67689273a0c7caed0d4c2e360 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y404-0102 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30 |
filingDate | 2008-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9325346f1bd95ca5eaf3111829f45ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b725646389ef59ec28355b9778b964de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aeaf3df39968f90f46e98f6fa976460 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a2af4d579187d55d505e7819318a8ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cd40342181ca23d18b4ec36311e5063 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b283afe13be1806072a1729e7674111c |
publicationDate | 2010-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-2153362-A2 |
titleOfInvention | Methods for selecting or designing modulators, based on the crystal structure of leukotriene c4 synthase (ltc4s) |
abstract | A method for selecting or designing a compound expected to modulate the activity of Leukotriene C4 synthase (LTC4S), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the catalytic site or a substrate binding region of LTC4S, wherein a three-dimensional structure of at least a part of the catalytic site or a substrate binding region of LTC4S is compared with a three-dimensional structure of a compound, and a compound that is predicted to interact with the said catalytic site or substrate binding region is selected. The selected compound may be predicted to bind to at least a part of a region of the structure termed the 'GSH substrate binding cavity' (formed by residues including residues Arg51, Arg30, Arg104, Gln53, Asn55, Glu58, Tyr59, Tyr93, Tyr97, Ile27, Pro37, Leu108 of full length human LTC4S, or equivalent residues); the 'lipophilic substrate binding crevice' (formed by residues including Ala20, Leu24, Ile27, Tyr59, Trp116, Ala112, Leu115, Leu108, Tyr109, Leu62, VaI119, Thr66, Val119 and Leu17, or equivalent residues); or the 'catalytic site' (formed by residues including Arg104 or Arg31, or equivalent residues). |
priorityDate | 2007-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.