http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2152330-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3b76a01728ea47f5e574b71ce6e73da |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2210-0004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2210-0076 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-2412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3691 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-507 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 |
| filingDate | 2008-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5405be564b6814f860b04394879643a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00ff0e4a367450e5bc219e98245816b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4631c4d0b1fcf341fafd9c3ba31b0cf3 |
| publicationDate | 2010-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2152330-A2 |
| titleOfInvention | Methods for pre-stressing and capping bioprosthetic tissue |
| abstract | A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post- implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock- absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent. |
| priorityDate | 2007-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.