http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2150273-A2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9cc2d8f832624f015bd24bec47ef697 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8132 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
filingDate | 2008-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73eda412b337da3bfe122dbece6c2b2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e5c7dde360251bebfd43a202be10f74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ea74f1033671f1bea6e9fc53ee4663 |
publicationDate | 2010-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-2150273-A2 |
titleOfInvention | Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
abstract | The present invention relates to a modified plasminogen activator inhibitor type- 1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI- 1, but is deficient in one or more functional activities as compared to the wild-type PAI- 1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following funtional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-I molecules and methods of using these pharmaceutical compositions for treatment. |
priorityDate | 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 3951.