| abstract |
Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. n A compound represented by the formula:n n, its pharmaceutically acceptable salt, or a solvate thereof, nwherein R 1 is optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycle or optionally substituted heterocyclealkyl, nX is -O-, -NR 3 -, -NR 3 C(=O)- or -NR 3 S(=O) 2 -, nR 2 is optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, nR 3 is hydrogen or optionally substituted alkyl. |