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publicationDate 2010-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2139987-A1
titleOfInvention Methods of protein production using anti-senescence compounds
abstract Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of an anti-senescence compound exhibit decreased levels of high molecular weight aggregates in the cell culture medium.
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