| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41120a1480fac7dff510d3d8b96d040b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 |
| filingDate |
2007-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d2c1d9e832d1be9f140f0e4928c4c8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89a1feac40baa61af47a2657aa705440
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4127ee881f4992f481512d565a7b8128
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddc73ddcb47465933014055658dc84a3 |
| publicationDate |
2010-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2139838-A2 |
| titleOfInvention |
A process for the preparation of 6-ý3-(1-adamantyl)-4-methoxyphenyl-2-naphtoic acid |
| abstract |
A process for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid from 2-(1-adamantyl)-4-bromanisolee is disclosed, based on transformation of 2-(1-adamantyl)-4-bromanisole into a Grignard's reagent by using metallic magnesium, anhydrous lithium chloride and dibromoethane followed by transmetallation with borates to 3-(adamantyl)-4-methoxyphenylboronic acid, wich is converted into 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid esters by Suzuki-Miyaura cross-coupling reaction with alkyl-6-halonaftoates catalyzed by Pd [0] or Pd/phosphine ligands and followed by basic hydrolysis in ethylene glycol or 1,2-propanediol of ester thus obtained into 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. |
| priorityDate |
2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |