http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2121945-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11c5b15ed30b74f97491f70cc04e20a9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10344 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8218 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8613 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-14 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
| filingDate | 2007-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_affdc79d04fb8d4111cdf9a04cc80011 |
| publicationDate | 2009-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2121945-A2 |
| titleOfInvention | Liposomally encapsulated hybrid adenovirus-semliki forest virus (sfv) vectors carrying rnai constructs and therapeutic genes for use against cancer targets and other diseases |
| abstract | A hybrid adenovirus Semliki Forest Virus (SFV) vector is provided which has a structure as shown in Figure 1, which may comprise 3' and 5' inverted terminal repeat (ITR) of adenovirus the packaging signal of adenovirus, the structural genes encoding the adenovirus hexon and penton proteins, fiber and knob proteins and which may be deleted in the E4 region, E2 region or in the both the E2 and E4 regions. The adenovirus vector may not require a helper virus coinfection for propagation in producer cell lines. The hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 endowed with enhanced cytotoxicity after infection of target cells and retaining the ability to replicate the 42S genome, which also comprises the therapeutic mRNA, in the cytoplasm or the hybrid vector may comprise a eukaryotic promoter controlling expression of the 42S genome of SFV comprising the nonstructural genes 1-4 containing two point mutations. In use, the hybrid vector further comprises cDNA encoding for microRNA (miRNA) and hairpin loops of short interfering RNA (siRNA) or cDNA encoding for double-stranded RNA (dsRNA). |
| priorityDate | 2006-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1324.