| abstract |
A strain of Francisella species in which gene FTT1564, or homologue thereof, has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein additional genes are also inactivated. Pharmaceutical compositions comprising said strains, together with methods of preventing and treating tularemia infection, which utilise such strains, are also described and claimed. |