| abstract |
New medical use of anthracycline antibiotics derivatives of general formula 1 and 2, wherein R1 is hydrogen or methoxy group, R2 is hydrogen or hydroxy group, R3 is hydroxy group in an axial or equatorial orientation, R4 and R5 are hydrogen or methyl group, R6 is 1-phenylethyl group or R5 and R6 together with a nitrogen atom are N,N-diethyl, N,N-dipropyl or N,N-dibutyl group, or R5 and R6 together with a nitrogen atom form N,N-1',4'-tetramethylene, N,N-3'-oxa-1',5'- pentamethylene, N,N-1',5'-pentamethylene, N,N-1',6'-hexamethylene, N1N- 1',7'-heptamethylene, N,N-3'-methylaza-1',5'-pentamethylene or 1-indolinyl group, whereas if X is HCI molecule, the compound is hydrochloride of a derivative of general formula 1 or if X is 0, the compound is a derivative in a free base form of general formula 1 wherein, these derivatives are used as active ingredients for preparation of a medicine for treatment of viral infections, preferably for treatment of infection caused by hepatitis C virus (HCV) and the pharmaceutical composition. |