| abstract |
An endovascular stent (20) for placement at a vascular injury site for inhibiting restenosis at the site comprises a body (22) having an open lattice structure formed of linked filaments (24, 26), and a drug-release coating carried on the filaments, the coating having a thickness of between 3-30 microns and composed of (i) 20 to 80 weight percent polymer substrate and (ii) 20 to 80 weight percent macrocyclic triene compound. The stent is expandable from a contracted condition, in which the stent can be delivered to a vascular injury site via catheter, and an expanded condition, in which the stent coating can be placed in contact with the vessel at the injury site. The coating is effective to release an amount of the compound to inhibit restenosis at the site. |