| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2a3a767ae32dfcda1f4e6642aeadc9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-69 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fbae5a31953fa5528ee825f079230ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a792b92a5f42d7d3110477734c5120c |
| publicationDate |
2009-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2105145-A1 |
| titleOfInvention |
Method for muscle-specific delivery lipid-conjugated oligonucleotides |
| abstract |
The invention describes a method for muscle-specific delivery of oligonucleotides to induce gene silencing by RNA interference or silencing of microRNAs in vivo. A liposome comprising triacylglycerol, phospholipids, glycerol and lipid-binding proteins aggregated via a linker molecule with a single- or double-stranded oligonucleotide that is stabilized by one or more oligonucleotide modifications is isolated from Intralipid and serves as tissue-specific carrier. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9078919-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8728724-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8148344-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163235-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8202848-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8513209-B2 |
| priorityDate |
2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |