http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2099911-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2008-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65caa2322d8c80be8dc962f55b8fef32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeb9bde4b25108cc590061fb5bf3e3f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60a4b7edb28b5f8de1d08a21a65e77fc |
| publicationDate | 2009-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2099911-A2 |
| titleOfInvention | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| abstract | Compositions for targeted mutagenesis of cell surface receptors for HIV and methods of their use are provided herein. The compositions include triplex-forming molecules that bind to duplex DNA in a sequence specific manner at target sites to form triple-stranded structures. The triplex-forming molecules can be triplex-forming oligonucleotides (TFOs) or peptide nucleic acids (PNAs). The triplex-forming molecules are useful to induce site-specific homologous recombination in mammalian cells when used in combination with donor oligonucleotides. The triplex-forming molecules target sites within or adjacent to genes that encodes cell surface receptors for human immunodeficiency virus (HIV). This binding stimulates homologous recombination of a donor oligonucleotide to cause mutations in HIV cell surface receptor genes that result in one or more deficiencies in the ability of the encoded receptor to bind to HIV and allow its transport into the cell. Methods for ex vivo and in vivo prophylaxis and therapy of HIV infection using the disclosed compositions are also provided. |
| priorityDate | 2007-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 298.