abstract |
Compounds of formula (I) are modulators of cannabinoid receptor CB1, useful for the treatment of obesity and diseases for which obesity is a risk factor: (I) wherein: X is a bond, Or-C(R10)(R11)-*. -C(R10)(R11)-O-*, -C(R10)(R11)CH2-*, -C(R10)(R11)CH2-O-*, -CH2C(R10)(R11)-*, -CH2C(R10)(R11)-O-*, or -CH2-O-C(R10)(R11)-*; Y is =O, =N(R9), =N(OR9), =CH(CN), =C(CN)2 or =N(CN); Z is a bond, -O- or -NH-; R1 and R2 are hydrogen, (CrC3)alkyl, (C3-C6)cycloalkyl or monocyclic heterocyclic; or R1 and R2 taken together with the nitrogen to which they are attached form a cyclic amino ring; R3 is hydrogen or a radical of formula -(O)a- AIk3 wherein a and AIk3 are as defined in the claims; R4 is a radical of formula -(O)b-(Alk1)p-(Q)r-(L)s-Q2 wherein b, p, r, s AIk1, L, Q1 and Q2 are as defined in the claims; or R3 and R4 taken together with the nitrogen to which they are attached form a cyclic amino ring; R5 is hydrogen -F, -Cl, -Br, -CN, (C1-C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, -COOH, tetrazole or -OR9; R6, R7 and R8 are hydrogen -F, -Cl, -Br, -CN, (C1-C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, or -OR9; and R9 R10 and R11 are as defined in the claims. |