http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2088435-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_589b4e7af26cc1f1fd30dee3d5cb9ced |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-974 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 |
| filingDate | 2008-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8aeb382feada604af03811c6cafbbea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef7d6f1f6f3a2685ea5e8ed54c7709cd |
| publicationDate | 2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2088435-A1 |
| titleOfInvention | Time-course measurement of enzymatic activity corrected for impacts of disturbances relating to the reaction of the enzyme with a substrate |
| abstract | The invention relates to time-course measurement of enzymatic activity corrected for impacts of disturbances relating to the reaction of the enzyme with a substrate. n The in vitro method of the invention is especially intended for the measurement of clotting or the fibrinolysis activity in vitro . n The invention enables to measure the exact time course of an enzymatic activity that develops and/or disappears in a reaction mixture, especially in a blood sample. n The invention thus relates to a method of determination of the course of an enzyme activity that is variable in time, wherein said activity is probed by conversion of a substrate of the enzyme, comprising, in a selected test set up and for a determined substrate of the enzyme, the determination of the velocity of signal production (dF diag /dt) resulting from a time curve of the signal (F diao =f(A)) obtained from splitting said substrate when it is contacted with a determined initially fixed concentration of the enzyme (E) and providing a "diagnostic plot" with the values of (dF diag /dt) against the signal (F diag ) and determining whether said diagnostic plot is either a straight line or a parabola and in the same test conditions, for a given test sample, the determination of the signal production (F exp ) resulting from splitting the substrate by the enzyme generating in and/or disappearing from the sample and providing the time curve of signal F exp =f(t); and transforming the obtained experimental value of the signal (F exp ) into an ideal value (F transf ) |
| priorityDate | 2008-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.