http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2086952-A2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85a5d37951510cc751b6ec1be98f8869 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-08 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-08 |
filingDate | 2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25fd09d70c7f776e5d248b14505b52a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1421d9d5391a07c191ce0edcfbc7390 |
publicationDate | 2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-2086952-A2 |
titleOfInvention | Method for the stereoselective synthesis of chiral epoxides by adh reduction of ketones substituted with alpha starting groups and cyclisation |
abstract | The invention relates to a method for producing chiral epoxides by reducing ketones substituted with a-starting groups with cell-free (R)- or (S)-selective alcohol dehydrogenases in the presence of a cofactor, and optionally a suitable system for the regeneration of the oxidised cofactor to form the chiral alcohols, and subsequent base-induced cyclisation to form the chiral epoxides (EQUATION 1) wherein LG can represent F, Cl, Br, I, OSO<SUB>2</SUB>Ar, OSO<SUB>2</SUB>R<SUB>4</SUB> or OP(O)OR<SUB>4</SUB>R<SUB>5</SUB> and R<SUB>1</SUB>, R<SUB>2</SUB> and R<SUB>3</SUB> independently represent hydrogen, a branched or unbranched, optionally substituted C<SUB>1</SUB>-C<SUB>20</SUB> alkyl radical, an optionally substituted C<SUB>3</SUB>-C<SUB>10 </SUB>cycloalkyl or alkenyl radical or an optionally substituted carbocyclic or heterocyclic aryl radical or a radical from the group consisting of CO<SUB>2</SUB>R<SUB>4</SUB>, CONR<SUB>4</SUB>R<SUB>5</SUB>, COSR<SUB>4</SUB>, CS<SUB>2</SUB>R<SUB>4</SUB>, C(NH)NR<SUB>4</SUB>R<SUB>5</SUB>, CN, CHaI<SUB>3</SUB>, OAr, SAr, OR<SUB>4</SUB>, SR<SUB>4</SUB>, CHO, OH, NR<SUB>4</SUB>R<SUB>5</SUB>, Cl, F, Br, I or SiR<SUB>4</SUB>R<SUB>5</SUB>R<SUB>6</SUB>, where<SUB/>R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> independently represent hydrogen, a branched or unbranched, optionally substituted C<SUB>1</SUB>-C<SUB>20</SUB> alkyl radical, an optionally substituted C<SUB>3</SUB>-C<SUB>10 </SUB>cycloalkyl or alkenyl radical or a substituted carbocylic or heterocyclic aryl radical, the intermediately formed chiral alcohol Il not being isolated. |
priorityDate | 2006-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 318.