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filingDate 2007-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2086526-A2
titleOfInvention Induction of an immune response against dengue virus using prime-boost approach
abstract The invention relates to methods for the induction of an immune response to dengue virus. The method of inducing an immune response against dengue virus comprising administration of a non-replicating immunogen followed by a boost with a tetravalent live attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regimen with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins.
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