Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18132 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-768 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-768 |
filingDate |
2008-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a29d8afb3c518638a80bef772832525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b912fa4313dad37601cfdbc5005f3a2d |
publicationDate |
2009-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2085092-A1 |
titleOfInvention |
Attenuated oncolytic paramyxoviruses encoding avian cytokines |
abstract |
The invention refers to a recombinant oncolytic RNA Newcastle Disease Virus for the treatment of a proliferative disease, comprising at least one transgene coding for an avian cytokine, wherein the recombinant oncolytic RNA Newcastle Disease Virus is obtainable from a velogenic or mesogenic oncolytic RNA Newcastle Disease Virus. Virus-mediated expression of the cytokine in the natural host cells leads to a reduced pathogenicity of the virus for avian species. Furthermore the virus genome can encode binding proteins, prodrug-converting enzymes or/and proteases. The selective expression of these molecules in virus-infected tumor cells increases the anti-tumor effect of the virus. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10035984-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103732236-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107787364-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013022764-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9719105-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10308913-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103732236-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767166-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11389495-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10251922-B2 |
priorityDate |
2008-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |