| abstract |
The subject of the invention is an oil-in-water adjuvant emulsion comprising at least: • squalene, An aqueous solvent, A nonionic surfactant which is a polyoxyethylene alkyl ether, A hydrophobic nonionic surfactant, thermoreversible, and 90% of the population density of oil drops has a size less than 200 nm.n n n The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, characterized in that the oil-in-water emulsion is obtained by a phase inversion method by variation of the temperature. |