| abstract |
Disclosed are urea compounds, stereoisomer, or pharmaceutical acceptable salt thereof, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related. diseases. Formula (I) wherein: X is C=O or SO2; Y is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalky!. aryl. substituted aryl, heteroaryl, and substituted heteroaryl; Z is independently selected from the group consisting of halogen and haloalkyl; n is an integer equal to 1, 2, or 3; and p is an integer equal to 1, 2, or 3, |