| abstract |
Compounds of the formula ( I) or pharmaceutically acceptable salts thereof, wherein X is a bond, -CH2CH2-, -CH=CH-, -CH2O-, -CH2NR-, -CH2S(O) -, CH2S(O)-, -O-,OCH2CH2S(O)2-, -CH2NRCO-, -CH2NRCH2-, (a), (b), (c), -NRS(O) 2NR-,-NHCHR-, or -NRS(O)2-; and wherein X can be inserted in both directions into formula (I); Y is a bond, -CHR- or -OCH2CH2-; R is hydrogen or lower alkyl; Ar1/Ar2 are independently from each other aryl or 5 to 10 membered heteroaryl, optionally substituted by lower alkyl, lower alkoxy, lower haloalkoxy, halogen, -CF3, -CH2OH, -CH2O-lower alkyl, 3 to 10 membered cycloalkyl, 5 to 10 membered heterocycloalkyl, -CH2O(CH2)2O-lower alkyl, -S(O)2-lower alkyl or -S(O)2NHR. |