http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2068882-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f910183edfd447ee781e6b9e34978b9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e83bceb0cb53690622741335fe9edea http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2eb691263b6037930f6faf8f2e71cca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 2007-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a00a08993ede93e47d04dcc516612c76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cda166aa3437f30ef683a7d2caad78c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_893d60adf1fec7ad37fad6cfb2af3d55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f371c18b093b3307d87e8d94ac663126 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d68f240a7cb8a214b389a9c1d6c61f8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f66f4251a5a9e3c58754c44f494e758c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85f2a8c98a4e23ed3f3c43a5484fa924 |
| publicationDate | 2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2068882-A2 |
| titleOfInvention | Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation |
| abstract | The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is -OC-R-COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is -OC-R-COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is -(CH2)nN+R3Y-, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je -(CH2)nR+Y-, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents -R-COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. |
| priorityDate | 2006-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 218.