http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2057279-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d60813bf897ef5a62663bc9e6ef135ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0052 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2007-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1600467344a5a1017cfe278dc2d7e16f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03ded339440c13b4273bbdb9d26ca7d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47838e3317e17caff30a42e204b69625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cfd129eac77e13c765a115b86e5e086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a973c2a49c59d7f2bdc5e560f64d1954 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04a591293ac7a0e1187b3d162dc6088c |
| publicationDate | 2009-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2057279-A2 |
| titleOfInvention | Bisubstrate fluorescent probe binding to protein kinases |
| abstract | This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to both ATP binding site and substrate protein/peptide binding domain of the kinase. High affinity of the probe (Kd = 1.0 nM towards cAMP-dependent protein kinase) affords the application of the enzymes at low concentration which leads to the substantial decrease of the consumption of the kinase. Due to the ability of the conjugates of oligo(D-arginine) with a ATP binding site targeted inhibitors of this invention to bind with high affinity to a wide spectrum of (basophilic) kinases, a single Fluorescent probe is applicable for assessment of inhibitory potency of compounds towards a great number of protein kinases. |
| priorityDate | 2006-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 904.