| abstract |
The invention relates to retinoid compounds of one of the following formulae: Formula 6 a; R = H D1 R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 10 a,R = H b; R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 11 a; R = H b; R =Me (i) para-CONHOH (u)meta-CONHOH (ui)orttho-CONH0H Formula 12 (i) PaIa-CO2H (R = H or Me. R' = H or Me) (ii) meta-CO2H (R = H or Me, R' = H orM) Formula 13 R = H or Me, R' = H or M or a salt thereof, and to the use of such compounds in the control of cell differentiation. |