abstract |
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH 2 , NR 5 or oxygen, X is CH or nitrogen, Y is a bond, CH 2 , oxygen or NR 6 , Z is CH or nitrogen, R 1 , R 2 are, independently, hydrogen or C 1 -C 6 alkyl, R 3 , R 4 are, independently, hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl or C 1 -C 6 haloalkoxy, and R 5 and R 6 are as further defined in the specification, and pharmaceutical acceptable salts thereof. |