abstract |
A method for preparing lymphocytes characterized in that the method includes the step of culturing lymphocytes in the presence of a modified recombinant fibronectin fragment, in which a part of heparin binding domains of fibronectin overlaps. The method of the present invention gives a high cell proliferation rate, and the lymphocytes obtained by the present invention can be suitably used, for example, in adoptive immunotherapy, so that a significant contribution to the field of medicine is expected. In addition, according to the present invention, a novel modified recombinant fibronectin fragment is provided. |